In-depth, evidence-based guides on prescription nootropics — how they work, how to use them safely, and what the research actually shows.
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All content is for educational purposes only. Not medical advice. Consult a doctor before using any of the above compounds.
New to cognitive enhancement? This guide cuts through the hype — what nootropics can realistically do, which compounds are worth researching, and how to approach self-experimentation safely.
A deep dive into how modafinil works, what the research says about its cognitive effects, optimal dosing strategies, and how to stack it responsibly.
Atomoxetine (Strattera) is an ADHD medication with a uniquely clean profile — no stimulant classification, no dopamine flooding. Here's what it actually does and who it suits.
Piracetam was synthesized in 1964 and literally gave us the word "nootropic." Half a century later, what does the evidence actually show? And why does everyone stack it with choline?
Popular nootropic combinations — from modafinil + piracetam to caffeine + L-theanine — ranked by evidence quality. What synergises, what cancels out, and what's just placebo.
Both reduce stress — but they work through completely different mechanisms and suit very different people. Here's the direct comparison that tells you which one to choose.
Both deliver choline to the brain, but they differ in bioavailability, additional effects, and best use cases. The evidence-based comparison for nootropic users and racetam stackers.
Piracetam, aniracetam, oxiracetam, pramiracetam, phenylpiracetam — same chemical family, very different characters. This guide maps each to the goals it actually suits.
Ranked by evidence: what to take before a study session, what builds over time, and what to avoid before exams. A practical protocol from prep to exam week.
Both are used off-label for cognitive enhancement — but they work through completely different mechanisms, suit different problems, and fail in different ways. The comparison most guides get wrong.
Why piracetam requires choline, how Alpha-GPC became the standard pairing, the protocol that actually works, and what the combination does to the brain — mechanistically explained.
Most nootropics research used male subjects. Sex differences in metabolism, hormonal cycling, and neurotransmitter baselines mean the standard advice doesn't always apply. Here's what the evidence says.
Why combining these two compounds outperforms either alone, what the clinical evidence from randomised trials shows, the optimal ratio, and where it fits alongside prescription nootropics.
A rigorous look at lion's mane — the nerve growth factor mechanism, what human trials found, why product quality varies enormously, and where it fits in a serious nootropic protocol.